Drug Susceptibility of Mycobacterium tuberculosisThrough the Mycolic Acid Index.
نویسندگان
چکیده
The methods accepted to determine antimicrobial drug susceptibility of mycobacteria are based on the determination of the microorganisms' growth on solid or liquid medium containing a specified concentration of a single drug.
منابع مشابه
Mycolic acid index susceptibility method for Mycobacterium tuberculosis.
A rapid drug susceptibility test to measure the susceptibility of Mycobacterium tuberculosis to isoniazid (INH) and rifampin (RIF) using clinical isolates and a newly defined mycolic acid index (MAI) was evaluated. A total of 200 clinical isolates of M. tuberculosis were tested for susceptibility or resistance to INH and RIF by the MAI susceptibility and indirect-proportion methods. Overall, th...
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Multidrug-resistant (MDR) Mycobacterium tuberculosis and extrensively drug-resistant (XDR) M. tuberculosis are emerging public health threats whose threats are compounded by the fact that current techniques for testing the susceptibility of M. tuberculosis require several days to weeks to complete. We investigated the use of high-performance liquid chromatography (HPLC)-based quantitation of my...
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A direct relationship was established between the rate of uptake of isoniazid and the action of this drug on in vivo mycolic acid synthesis in Mycobacterium tuberculosis H37Ra. The rate of uptake of isoniazid increased linearly with its external concentration and appeared to reach a maximal value of 52 pmoles per hr per 10(9) cells at an external concentration of about 13 mum. Correspondingly, ...
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ورودعنوان ژورنال:
- Methods in molecular medicine
دوره 48 شماره
صفحات -
تاریخ انتشار 2001